CovidChloroV1, Main, Exploration, bibRecord, 000290

Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU

Identifieur interne : 000290 ( Main/Exploration ); précédent : 000289; suivant : 000291

Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU

Auteurs : Nursel Çal K Ba Aran [Turquie] ; O Uz Abdullah Uyaro Lu [Turquie] ; Gülçin Telli Dizman [Turquie] ; Lale Öz K [Turquie] ; Taha Koray Ahin [Turquie] ; Zahit Ta [Turquie] ; Ahmet Ça Kan Nkaya [Turquie] ; Sevilay Karahan [Turquie] ; Ehnaz Alp [Turquie] ; Alpaslan Alp [Turquie] ; Gökhan Metan [Turquie] ; P Nar Zarakol [Turquie] ; Gülay Sain Güven [Turquie] ; Erife Gül Öz [Turquie] ; Arzu Topeli [Turquie] ; Ömrüm Uzun [Turquie] ; Murat Akova [Turquie] ; Serhat Ünal [Turquie]

Source :

Turkish journal of medical sciences [ 1303-6165 ] ; 2021.

RBID : pubmed:32718127

Descripteurs français

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Amides (therapeutic use), Anti-Bacterial Agents (therapeutic use), Antiviral Agents (therapeutic use), Azithromycin (therapeutic use), COVID-19 (drug therapy), Drug Therapy, Combination (MeSH), Early Medical Intervention (MeSH), Early Warning Score (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Intensive Care Units (MeSH), Length of Stay (MeSH), Male (MeSH), Middle Aged (MeSH), Prospective Studies (MeSH), Pyrazines (therapeutic use), SARS-CoV-2 (MeSH), Severity of Illness Index (MeSH), Treatment Outcome (MeSH), Young Adult (MeSH).
MESH :
- chemical , therapeutic use : Amides, Anti-Bacterial Agents, Antiviral Agents, Azithromycin, Hydroxychloroquine, Pyrazines.
- drug therapy : COVID-19.
- Adult, Aged, Aged, 80 and over, Drug Therapy, Combination, Early Medical Intervention, Early Warning Score, Female, Hospitalization, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Prospective Studies, SARS-CoV-2, Severity of Illness Index, Treatment Outcome, Young Adult.

Abstract

Background/aim

Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital.

Materials and methods

This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected.

Results

We included 174 consecutive probable/confirmed COVID-19 adult patients hospitalized in the Internal Medicine wards of the University Adult Hospital between March 20 and April 30, 2020. The median age was 45.5 (19–92) years and 91 patients (52.3%) were male. One hundred and twenty (69%) were confirmed microbiologically, 41 (23.5%) were radiologically diagnosed, and 13 (7.5%) were clinically suspected (negative microbiological and radiological findings compatible with COVID-19); 35 (20.1%) had mild, 107 (61.5%) moderate disease, and 32 (18.4%) had severe pneumonia. Out of 171 cases, 130 (74.3%) showed pneumonia; 80 were typical, and 50 showed indeterminate infiltration for COVID-19. Patients were admitted within a median of 3 days (0-14 days) after symptoms appear. The median duration of hospitalization was 4 days (0-28 days). In this case series, 13.2% patients were treated with hydroxychloroquine alone, 64.9% with hydroxychloroquine plus azithromycin, and 18.4% with regimens including favipiravir. A total of 15 patients (8.5%) were transferred to the ICU. Four patients died (2.2%).

Conclusion

In our series, 174 patients were admitted to the hospital wards for COVID-19, 69% were confirmed with PCR and/or antibody test. At the time of admission, nearly one fifth of the patients had severe diseases. Of the patients, 95.4% received hydroxychloroquine alone or in combination. The overall case fatality rate was 2.2%.

DOI: 10.3906/sag-2006-173
PubMed: 32718127

Affiliations:

Turquie

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Le document en format XML

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<author><name sortKey=" Nkaya, Ahmet Ca Kan" sort=" Nkaya, Ahmet Ca Kan" uniqKey=" Nkaya A" first="Ahmet Ça Kan" last=" Nkaya">Ahmet Ça Kan  Nkaya</name>
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<author><name sortKey="Karahan, Sevilay" sort="Karahan, Sevilay" uniqKey="Karahan S" first="Sevilay" last="Karahan">Sevilay Karahan</name>
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<author><name sortKey="Zarakol, P Nar" sort="Zarakol, P Nar" uniqKey="Zarakol P" first="P Nar" last="Zarakol">P Nar Zarakol</name>
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<author><name sortKey="Sain Guven, Gulay" sort="Sain Guven, Gulay" uniqKey="Sain Guven G" first="Gülay" last="Sain Güven">Gülay Sain Güven</name>
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<author><name sortKey="Oz,  Erife Gul" sort="Oz,  Erife Gul" uniqKey="Oz  " first=" Erife Gül" last="Öz"> Erife Gül Öz</name>
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<author><name sortKey="Topeli, Arzu" sort="Topeli, Arzu" uniqKey="Topeli A" first="Arzu" last="Topeli">Arzu Topeli</name>
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<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Internal Medicine, Intensive Care Division, Faculty of Medicine, Hacettepe University, Ankara</wicri:regionArea>
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<author><name sortKey="Uzun, Omrum" sort="Uzun, Omrum" uniqKey="Uzun O" first="Ömrüm" last="Uzun">Ömrüm Uzun</name>
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<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara</wicri:regionArea>
<wicri:noRegion>Ankara</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akova, Murat" sort="Akova, Murat" uniqKey="Akova M" first="Murat" last="Akova">Murat Akova</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara</wicri:regionArea>
<wicri:noRegion>Ankara</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Unal, Serhat" sort="Unal, Serhat" uniqKey="Unal S" first="Serhat" last="Ünal">Serhat Ünal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara</wicri:regionArea>
<wicri:noRegion>Ankara</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Turkish journal of medical sciences</title>
<idno type="eISSN">1303-6165</idno>
<imprint><date when="2021" type="published">2021</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Amides (therapeutic use)</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Azithromycin (therapeutic use)</term>
<term>COVID-19 (drug therapy)</term>
<term>Drug Therapy, Combination (MeSH)</term>
<term>Early Medical Intervention (MeSH)</term>
<term>Early Warning Score (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Intensive Care Units (MeSH)</term>
<term>Length of Stay (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Pyrazines (therapeutic use)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Amides (usage thérapeutique)</term>
<term>Antibactériens (usage thérapeutique)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Association de médicaments (MeSH)</term>
<term>Azithromycine (usage thérapeutique)</term>
<term>Durée du séjour (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Intervention médicale précoce (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pyrazines (usage thérapeutique)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Unités de soins intensifs (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amides</term>
<term>Anti-Bacterial Agents</term>
<term>Antiviral Agents</term>
<term>Azithromycin</term>
<term>Hydroxychloroquine</term>
<term>Pyrazines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Amides</term>
<term>Antibactériens</term>
<term>Antiviraux</term>
<term>Azithromycine</term>
<term>Hydroxychloroquine</term>
<term>Pyrazines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Drug Therapy, Combination</term>
<term>Early Medical Intervention</term>
<term>Early Warning Score</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Length of Stay</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>SARS-CoV-2</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Association de médicaments</term>
<term>Durée du séjour</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Intervention médicale précoce</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Unités de soins intensifs</term>
<term>Études prospectives</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>Background/aim</b>
</p>
<p>Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Materials and methods</b>
</p>
<p>This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>We included 174 consecutive probable/confirmed COVID-19 adult patients hospitalized in the Internal Medicine wards of the University Adult Hospital between March 20 and April 30, 2020. The median age was 45.5 (19–92) years and 91 patients (52.3%) were male. One hundred and twenty (69%) were confirmed microbiologically, 41 (23.5%) were radiologically diagnosed, and 13 (7.5%) were clinically suspected (negative microbiological and radiological findings compatible with COVID-19); 35 (20.1%) had mild, 107 (61.5%) moderate disease, and 32 (18.4%) had severe pneumonia. Out of 171 cases, 130 (74.3%) showed pneumonia; 80 were typical, and 50 showed indeterminate infiltration for COVID-19. Patients were admitted within a median of 3 days (0-14 days) after symptoms appear. The median duration of hospitalization was 4 days (0-28 days). In this case series, 13.2% patients were treated with hydroxychloroquine alone, 64.9% with hydroxychloroquine plus azithromycin, and 18.4% with regimens including favipiravir. A total of 15 patients (8.5%) were transferred to the ICU. Four patients died (2.2%).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusion</b>
</p>
<p>In our series, 174 patients were admitted to the hospital wards for COVID-19, 69% were confirmed with PCR and/or antibody test. At the time of admission, nearly one fifth of the patients had severe diseases. Of the patients, 95.4% received hydroxychloroquine alone or in combination. The overall case fatality rate was 2.2%.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32718127</PMID>
<DateCompleted><Year>2021</Year>
<Month>05</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>05</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1303-6165</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>51</Volume>
<Issue>2</Issue>
<PubDate><Year>2021</Year>
<Month>04</Month>
<Day>30</Day>
</PubDate>
</JournalIssue>
<Title>Turkish journal of medical sciences</Title>
<ISOAbbreviation>Turk J Med Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU</ArticleTitle>
<Pagination><MedlinePgn>411-420</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3906/sag-2006-173</ELocationID>
<Abstract><AbstractText Label="Background/aim">Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital.</AbstractText>
<AbstractText Label="Materials and methods">This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected.</AbstractText>
<AbstractText Label="Results">We included 174 consecutive probable/confirmed COVID-19 adult patients hospitalized in the Internal Medicine wards of the University Adult Hospital between March 20 and April 30, 2020. The median age was 45.5 (19–92) years and 91 patients (52.3%) were male. One hundred and twenty (69%) were confirmed microbiologically, 41 (23.5%) were radiologically diagnosed, and 13 (7.5%) were clinically suspected (negative microbiological and radiological findings compatible with COVID-19); 35 (20.1%) had mild, 107 (61.5%) moderate disease, and 32 (18.4%) had severe pneumonia. Out of 171 cases, 130 (74.3%) showed pneumonia; 80 were typical, and 50 showed indeterminate infiltration for COVID-19. Patients were admitted within a median of 3 days (0-14 days) after symptoms appear. The median duration of hospitalization was 4 days (0-28 days). In this case series, 13.2% patients were treated with hydroxychloroquine alone, 64.9% with hydroxychloroquine plus azithromycin, and 18.4% with regimens including favipiravir. A total of 15 patients (8.5%) were transferred to the ICU. Four patients died (2.2%).</AbstractText>
<AbstractText Label="Conclusion">In our series, 174 patients were admitted to the hospital wards for COVID-19, 69% were confirmed with PCR and/or antibody test. At the time of admission, nearly one fifth of the patients had severe diseases. Of the patients, 95.4% received hydroxychloroquine alone or in combination. The overall case fatality rate was 2.2%.</AbstractText>
<CopyrightInformation>This work is licensed under a Creative Commons Attribution 4.0 International License.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Çalık Başaran</LastName>
<ForeName>Nursel</ForeName>
<Initials>N</Initials>
<Identifier Source="ORCID">0000-0002-1290-6905</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uyaroğlu</LastName>
<ForeName>Oğuz Abdullah</ForeName>
<Initials>OA</Initials>
<Identifier Source="ORCID">0000-0003-0440-2026</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Telli Dizman</LastName>
<ForeName>Gülçin</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">0000-0001-8195-3345</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Özışık</LastName>
<ForeName>Lale</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0002-3494-8997</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Şahin</LastName>
<ForeName>Taha Koray</ForeName>
<Initials>TK</Initials>
<Identifier Source="ORCID">0000-0002-3590-0426</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taş</LastName>
<ForeName>Zahit</ForeName>
<Initials>Z</Initials>
<Identifier Source="ORCID">0000-0003-1292-5951</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>İnkaya</LastName>
<ForeName>Ahmet Çağkan</ForeName>
<Initials>AÇ</Initials>
<Identifier Source="ORCID">0000-0001-7943-8715</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karahan</LastName>
<ForeName>Sevilay</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0002-8692-7266</Identifier>
<AffiliationInfo><Affiliation>Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alp</LastName>
<ForeName>Şehnaz</ForeName>
<Initials>Ş</Initials>
<Identifier Source="ORCID">0000-0001-9424-8346</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alp</LastName>
<ForeName>Alpaslan</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0001-7856-7590</Identifier>
<AffiliationInfo><Affiliation>Department of Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Metan</LastName>
<ForeName>Gökhan</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">0000-0002-2676-4557</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zarakol</LastName>
<ForeName>Pınar</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">0000-0003-4918-4085</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sain Güven</LastName>
<ForeName>Gülay</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">0000-0001-8176-9767</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Öz</LastName>
<ForeName>Şerife Gül</ForeName>
<Initials>ŞG</Initials>
<Identifier Source="ORCID">0000-0002-5197-445X</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Topeli</LastName>
<ForeName>Arzu</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0002-5874-9087</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Intensive Care Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uzun</LastName>
<ForeName>Ömrüm</ForeName>
<Initials>Ö</Initials>
<Identifier Source="ORCID">0000-0003-4721-0139</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Akova</LastName>
<ForeName>Murat</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0002-6904-9473</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ünal</LastName>
<ForeName>Serhat</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0003-1184-4711</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2021</Year>
<Month>04</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Turkey</Country>
<MedlineTA>Turk J Med Sci</MedlineTA>
<NlmUniqueID>9441758</NlmUniqueID>
<ISSNLinking>1300-0144</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000577">Amides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011719">Pyrazines</NameOfSubstance>
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<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
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<Chemical><RegistryNumber>83905-01-5</RegistryNumber>
<NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EW5GL2X7E0</RegistryNumber>
<NameOfSubstance UI="C462182">favipiravir</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000577" MajorTopicYN="N">Amides</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017963" MajorTopicYN="N">Azithromycin</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061345" MajorTopicYN="N">Early Medical Intervention</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000080162" MajorTopicYN="N">Early Warning Score</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="Y">Hospitalization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011719" MajorTopicYN="N">Pyrazines</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">favipiravir</Keyword>
<Keyword MajorTopicYN="Y">hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="Y">noncritical illness</Keyword>
</KeywordList>
<CoiStatement>The authors declare that they have no conflict of interest. This study was carried out without any support from funding agencies in the public, commercial, or nonprofit sectors.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>06</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>7</Month>
<Day>29</Day>
<Hour>6</Hour>
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<ArticleId IdType="doi">10.3906/sag-2006-173</ArticleId>
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<affiliations><list><country><li>Turquie</li>
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<name sortKey="Alp,  Ehnaz" sort="Alp,  Ehnaz" uniqKey="Alp  " first=" Ehnaz" last="Alp"> Ehnaz Alp</name>
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<name sortKey="Karahan, Sevilay" sort="Karahan, Sevilay" uniqKey="Karahan S" first="Sevilay" last="Karahan">Sevilay Karahan</name>
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<name sortKey="Oz,  Erife Gul" sort="Oz,  Erife Gul" uniqKey="Oz  " first=" Erife Gül" last="Öz"> Erife Gül Öz</name>
<name sortKey="Sain Guven, Gulay" sort="Sain Guven, Gulay" uniqKey="Sain Guven G" first="Gülay" last="Sain Güven">Gülay Sain Güven</name>
<name sortKey="Ta, Zahit" sort="Ta, Zahit" uniqKey="Ta Z" first="Zahit" last="Ta">Zahit Ta</name>
<name sortKey="Telli Dizman, Gulcin" sort="Telli Dizman, Gulcin" uniqKey="Telli Dizman G" first="Gülçin" last="Telli Dizman">Gülçin Telli Dizman</name>
<name sortKey="Topeli, Arzu" sort="Topeli, Arzu" uniqKey="Topeli A" first="Arzu" last="Topeli">Arzu Topeli</name>
<name sortKey="Unal, Serhat" sort="Unal, Serhat" uniqKey="Unal S" first="Serhat" last="Ünal">Serhat Ünal</name>
<name sortKey="Uyaro Lu, O Uz Abdullah" sort="Uyaro Lu, O Uz Abdullah" uniqKey="Uyaro Lu O" first="O Uz Abdullah" last="Uyaro Lu">O Uz Abdullah Uyaro Lu</name>
<name sortKey="Uzun, Omrum" sort="Uzun, Omrum" uniqKey="Uzun O" first="Ömrüm" last="Uzun">Ömrüm Uzun</name>
<name sortKey="Zarakol, P Nar" sort="Zarakol, P Nar" uniqKey="Zarakol P" first="P Nar" last="Zarakol">P Nar Zarakol</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000290 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000290 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidChloroV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32718127
   |texte=   Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32718127" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidChloroV1

This area was generated with Dilib version V0.6.38.
Data generation: Sat May 22 17:02:32 2021. Site generation: Sat May 22 17:06:52 2021

	Serveur d'exploration COVID et hydrochloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration COVID et hydrochloroquine

Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU

Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki